The p62 encoding gene was then isolated and termed sequestosome 1 The protein was the first adaptor involved in selective autophagy identified in
An advantage to monitoring p62 to measure autophagic flux is that lysosomal inhibitors are not necessary, because unlike LC3-II, p62 does not usually increase As an autophagic cargo receptor, p62 participates in the ageing process through both autophagy-dependent and -independent mechanisms Next, we summarize in
u31 เครดิตฟรี 188 ทางเข้า TSC2-null cells depend upon p62 to maintain cellular redox homeostasis and cell survival through preservation of cellular glutathione p62 contains an LC3-interacting region and is believed to be a substrate for selective autophagy In addition, p62 contains a domain that binds ubiquitin chains
